AFAP1

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Actin filament associated protein 1
Identifiers
Symbols AFAP1 ; AFAP; AFAP-110; AFAP110
External IDs OMIM608252 MGI1917542 HomoloGene11009 GeneCards: AFAP1 Gene
RNA expression pattern
PBB GE AFAP1 203563 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60312 70292
Ensembl ENSG00000196526 ENSMUSG00000029094
UniProt Q8N556 Q80YS6
RefSeq (mRNA) NM_001134647 NM_027373
RefSeq (protein) NP_001128119 NP_081649
Location (UCSC) Chr 4:
7.76 – 7.94 Mb
Chr 5:
35.89 – 36 Mb
PubMed search [1] [2]

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[1][2][3][4]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[4]

References[edit]

  1. ^ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. 
  2. ^ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. 
  3. ^ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843. 
  4. ^ a b "Entrez Gene: AFAP1 actin filament associated protein 1". 

Further reading[edit]