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Actin filament associated protein 1
Symbols AFAP1 ; AFAP; AFAP-110; AFAP110
External IDs OMIM608252 MGI1917542 HomoloGene11009 GeneCards: AFAP1 Gene
RNA expression pattern
PBB GE AFAP1 203563 at tn.png
More reference expression data
Species Human Mouse
Entrez 60312 70292
Ensembl ENSG00000196526 ENSMUSG00000029094
UniProt Q8N556 Q80YS6
RefSeq (mRNA) NM_001134647 NM_027373
RefSeq (protein) NP_001128119 NP_081649
Location (UCSC) Chr 4:
7.76 – 7.94 Mb
Chr 5:
35.89 – 36 Mb
PubMed search [1] [2]

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[1][2][3][4]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[4]


  1. ^ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. 
  2. ^ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. 
  3. ^ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843. 
  4. ^ a b "Entrez Gene: AFAP1 actin filament associated protein 1". 

Further reading[edit]