AGXT

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Alanine-glyoxylate aminotransferase
Protein AGXT PDB 1h0c.png
PDB rendering based on 1h0c.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AGXT ; AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6
External IDs OMIM604285 MGI1329033 HomoloGene37251 GeneCards: AGXT Gene
EC number 2.6.1.44, 2.6.1.51
RNA expression pattern
PBB GE AGXT 206957 at tn.png
PBB GE AGXT 210327 s at tn.png
PBB GE AGXT 210326 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 189 11611
Ensembl ENSG00000172482 ENSMUSG00000026272
UniProt P21549 O35423
RefSeq (mRNA) NM_000030 NM_001276710
RefSeq (protein) NP_000021 NP_001263639
Location (UCSC) Chr 2:
241.81 – 241.82 Mb
Chr 1:
93.14 – 93.15 Mb
PubMed search [1] [2]

Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.[1][2][3]

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria.[3]

References[edit]

  1. ^ Nishiyama K, Funai T, Katafuchi R, Hattori F, Onoyama K, Ichiyama A (Jul 1991). "Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene". Biochem Biophys Res Commun 176 (3): 1093–9. doi:10.1016/0006-291X(91)90396-O. PMID 2039493. 
  2. ^ Purdue PE, Lumb MJ, Fox M, Griffo G, Hamon-Benais C, Povey S, Danpure CJ (Jul 1991). "Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase". Genomics 10 (1): 34–42. doi:10.1016/0888-7543(91)90481-S. PMID 2045108. 
  3. ^ a b "Entrez Gene: AGXT alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)". 

External links[edit]

Further reading[edit]