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AHNAK nucleoprotein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM103390 MGI1316648 HomoloGene67425 GeneCards: AHNAK Gene
RNA expression pattern
PBB GE AHNAK 211986 at tn.png
More reference expression data
Species Human Mouse
Entrez 79026 66395
Ensembl ENSG00000124942 ENSMUSG00000069833
UniProt Q09666 E9Q616
RefSeq (mRNA) NM_001620 NM_001039959
RefSeq (protein) NP_001611 NP_001035048
Location (UCSC) Chr 11:
62.2 – 62.32 Mb
Chr 19:
8.99 – 9.08 Mb
PubMed search [1] [2]

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.[1][2][3] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.[4] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. [5]


AHNAK has been shown to interact with S100B.[6]


  1. ^ James MR, Richard CW 3rd, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A et al. (Jan 1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nat Genet 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395. 
  2. ^ Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (Aug 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB J 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988. 
  3. ^ "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)". 
  4. ^ Hieda Y, Tsukita S, Tsukita S (Oct 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque.". J Cell Biol. 109 (4): 1511–1518. doi:10.1083/jcb.109.4.1511. PMC 2115823. PMID 2677021. 
  5. ^ Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells.". Cancer Res. 70 (9): 3780–3790. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789. 
  6. ^ Gentil, B J; Delphin C; Mbele G O; Deloulme J C; Ferro M; Garin J; Baudier J (Jun 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". J. Biol. Chem. (United States) 276 (26): 23253–61. doi:10.1074/jbc.M010655200. ISSN 0021-9258. PMID 11312263. 

Further reading[edit]