From Wikipedia, the free encyclopedia
Jump to: navigation, search
AHNAK nucleoprotein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM103390 MGI1316648 HomoloGene67425 GeneCards: AHNAK Gene
RNA expression pattern
PBB GE AHNAK 211986 at tn.png
More reference expression data
Species Human Mouse
Entrez 79026 66395
Ensembl ENSG00000124942 ENSMUSG00000069833
UniProt Q09666 E9Q616
RefSeq (mRNA) NM_001620 NM_001039959
RefSeq (protein) NP_001611 NP_001035048
Location (UCSC) Chr 11:
62.2 – 62.32 Mb
Chr 19:
8.99 – 9.08 Mb
PubMed search [1] [2]

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.[1][2][3] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.[4] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. [5]


AHNAK has been shown to interact with S100B.[6]


  1. ^ James MR, Richard CW 3rd, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, et al. (Jan 1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nat Genet 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395. 
  2. ^ Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (Aug 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB J 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988. 
  3. ^ "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)". 
  4. ^ Hieda Y, Tsukita S, Tsukita S (Oct 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque.". J Cell Biol. 109 (4): 1511–1518. doi:10.1083/jcb.109.4.1511. PMC 2115823. PMID 2677021. 
  5. ^ Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells.". Cancer Res. 70 (9): 3780–3790. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789. 
  6. ^ Gentil, B J; Delphin C; Mbele G O; Deloulme J C; Ferro M; Garin J; Baudier J (Jun 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". J. Biol. Chem. (United States) 276 (26): 23253–61. doi:10.1074/jbc.M010655200. ISSN 0021-9258. PMID 11312263. 

Further reading[edit]