AIDS-related lymphoma

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AIDS-related lymphoma
Classification and external resources
MeSH D016483

AIDS-related lymphoma describes lymphomas occurring in patients with acquired immunodeficiency syndrome (AIDS).[1][2]

A lymphoma is a type of cancer arising from lymphoid cells. In AIDS, the incidences of non-Hodgkin's lymphoma, primary cerebral lymphoma and Hodgkin's disease are all increased. There are three different varieties of AIDS-related lymphoma: Diffuse large B-cell lymphoma, B-cell immunoblastic lymphoma, and Burkitt's lymphoma (small non-cleaved cell lymphoma).[3]

Symptoms[edit]

The symptoms of AIDS-related lymphoma can include: weight loss, fever, and night sweats.[3]

Non-Hodgkin's lymphoma[edit]

Non-Hodgkin's lymphoma (NHL) is present in about 1-3% of HIV seropositive people at the time of the initial diagnosis of HIV. However, it is believed that such patients have been seropositive for a prolonged period, but have simply not had their infections recognized previously.[4] This is so because immunodysregulation must exist for an extended interval of time, in order for a lymphoproliferative process to evolve in that context.[5][6]

Primary cerebral lymphoma[edit]

Primary cerebral lymphoma (or primary central nervous system lymphoma) is a form of NHL. It is very rare in immunocompetent people, with an incidence of 5–30 cases per million person-years. However the incidence in immunocompromised individuals is greatly increased, up to 100 per million person-years.

Primary cerebral lymphoma is strongly associated with Epstein-Barr virus (EBV).[7] The presence of EBV DNA in cerebrospinal fluid is highly suggestive of primary cerebral lymphoma.

Treatment of AIDS patients with antiretroviral drugs reduces the incidence of primary cerebral lymphoma.

Hodgkin's disease[edit]

The incidence of Hodgkin's disease in the general population is about 10–30 per million person-years. This increases to 170 per million person-years in HIV positive patients.

See also[edit]

References[edit]

  1. ^ Besson C, Goubar A, Gabarre J, et al. (October 2001). "Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy". Blood 98 (8): 2339–44. doi:10.1182/blood.V98.8.2339. PMID 11588028. 
  2. ^ Rigolet A, Bossi P, Caumes E, et al. (September 2001). "Caractéristiques épidémiologiques et évolution de l'incidence des lymphomes cérébraux primitifs observés chez 80 patients infectés par le VIH entre 1983 et 1999" [Epidemiological features and incidence trends of primary cerebral lymphomas observed in 80 HIV-infected patients from 1983 to 1999]. Pathologie-biologie (in French) 49 (7): 572–5. doi:10.1016/S0369-8114(01)00206-1. PMID 11642021. 
  3. ^ a b "AIDS-Related Lymphoma Treatment (PDQ®) - National Cancer Institute". Cancer.gov. 2012-05-18. Retrieved 2012-05-30. 
  4. ^ Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK. Immunodeficiency-associated lymphomas. Blood Rev 2008 Sep;22(5):261-281.
  5. ^ Ibid.
  6. ^ Grulich AE, Wan X, Law MG, Milliken ST, Lewis CR, Garsia RJ, Gold J, Finlayson RJ, Cooper DA, Kaldor JM. B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS. AIDS 2000 Jan 28;14(2):133-140.
  7. ^ "Primary lymphoma of the brain: MedlinePlus Medical Encyclopedia". Nlm.nih.gov. Retrieved 2012-05-30. 

External links[edit]