AKAP13

From Wikipedia, the free encyclopedia
Jump to: navigation, search
A kinase (PRKA) anchor protein 13
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AKAP13 ; AKAP-13; AKAP-Lbc; ARHGEF13; BRX; HA-3; Ht31; LBC; PRKA13; PROTO-LB; PROTO-LBC; c-lbc; p47
External IDs OMIM604686 MGI2676556 HomoloGene4903 GeneCards: AKAP13 Gene
Orthologs
Species Human Mouse
Entrez 11214 75547
Ensembl ENSG00000170776 ENSMUSG00000066406
UniProt Q12802 E9PVD4
RefSeq (mRNA) NM_001270546 NM_029332
RefSeq (protein) NP_001257475 NP_083608
Location (UCSC) Chr 15:
85.92 – 86.29 Mb
Chr 7:
75.46 – 75.75 Mb
PubMed search [1] [2]

A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.[1][2][3]

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.[3]

Interactions[edit]

AKAP13 has been shown to interact with Estrogen receptor alpha,[1] CTNNAL1[4] and PRKAR2A.[5][6]

References[edit]

  1. ^ a b Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (Jul 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action". Oncogene 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117. 
  2. ^ Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (Sep 1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J Biol Chem 266 (22): 14188–92. PMID 1860836. 
  3. ^ a b "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13". 
  4. ^ Park, Brian; Nguyen Nhan T; Dutt Parmesh; Merdek Keith D; Bashar Mariam; Sterpetti Paola; Tosolini Alessandra; Testa Joseph R; Toksoz Deniz (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. (United States) 277 (47): 45361–70. doi:10.1074/jbc.M202447200. ISSN 0021-9258. PMID 12270917. 
  5. ^ Alto, Neal M; Soderling Scott H; Hoshi Naoto; Langeberg Lorene K; Fayos Rosa; Jennings Patricia A; Scott John D (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (8): 4445–50. doi:10.1073/pnas.0330734100. ISSN 0027-8424. PMC 153575. PMID 12672969. 
  6. ^ Carr, D W; Hausken Z E; Fraser I D; Stofko-Hahn R E; Scott J D (Jul 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J. Biol. Chem. (UNITED STATES) 267 (19): 13376–82. ISSN 0021-9258. PMID 1618839. 

Further reading[edit]