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A kinase (PRKA) anchor protein 6
Symbols AKAP6 ; ADAP100; ADAP6; AKAP100; PRKA6; mAKAP
External IDs OMIM604691 MGI3050566 HomoloGene3157 GeneCards: AKAP6 Gene
Species Human Mouse
Entrez 9472 238161
Ensembl ENSG00000151320 ENSMUSG00000061603
UniProt Q13023 Q3UHI8
RefSeq (mRNA) NM_004274 NM_198111
RefSeq (protein) NP_004265 NP_932779
Location (UCSC) Chr 14:
32.8 – 33.3 Mb
Chr 12:
52.7 – 53.15 Mb
PubMed search [1] [2]

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.[1][2][3]

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.[3]


AKAP6 has been shown to interact with Ryanodine receptor 2[4][5] and PDE4A.[6]


  1. ^ McCartney S, Little BM, Langeberg LK, Scott JD (May 1995). "Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum". J Biol Chem 270 (16): 9327–33. doi:10.1074/jbc.270.16.9327. PMID 7721854. 
  2. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  3. ^ a b "Entrez Gene: AKAP6 A kinase (PRKA) anchor protein 6". 
  4. ^ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell (UNITED STATES) 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164. 
  5. ^ Marx, S O; Reiken S; Hisamatsu Y; Gaburjakova M; Gaburjakova J; Yang Y M; Rosemblit N; Marks A R (May 2001). "Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers". J. Cell Biol. (United States) 153 (4): 699–708. doi:10.1083/jcb.153.4.699. ISSN 0021-9525. PMC 2192391. PMID 11352932. 
  6. ^ Dodge, K L; Khouangsathiene S; Kapiloff M S; Mouton R; Hill E V; Houslay M D; Langeberg L K; Scott J D (April 2001). "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". EMBO J. (England) 20 (8): 1921–30. doi:10.1093/emboj/20.8.1921. ISSN 0261-4189. PMC 125429. PMID 11296225. 

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