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Aldo-keto reductase family 1, member C1
Protein AKR1C1 PDB 1ihi.png
PDB rendering based on 1ihi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AKR1C1 ; 2-ALPHA-HSD; 20-ALPHA-HSD; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; MBAB
External IDs OMIM600449 MGI1933427 HomoloGene134114 ChEMBL: 5905 GeneCards: AKR1C1 Gene
EC number,,
RNA expression pattern
PBB GE AKR1C1 204151 x at tn.png
PBB GE AKR1C1 209699 x at tn.png
PBB GE AKR1C1 211653 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1645 77337
Ensembl ENSG00000187134 ENSMUSG00000021207
UniProt Q04828 Q91WR5
RefSeq (mRNA) NM_001353 NM_029901
RefSeq (protein) NP_001344 NP_084177
Location (UCSC) Chr 10:
4.93 – 5.03 Mb
Chr 13:
4.57 – 4.59 Mb
PubMed search [1] [2]

Aldo-keto reductase family 1 member C1 is an enzyme that in humans is encoded by the AKR1C1 gene.[1][2]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.[2]


  1. ^ Ciaccio PJ, Tew KD (Jul 1994). "cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase". Biochim Biophys Acta 1186 (1-2): 129–32. doi:10.1016/0005-2728(94)90144-9. PMID 8011662. 
  2. ^ a b "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)". 

Further reading[edit]