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Activated leukocyte cell adhesion molecule
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ALCAM ; CD166; MEMD
External IDs OMIM601662 MGI1313266 HomoloGene1229 GeneCards: ALCAM Gene
Species Human Mouse
Entrez 214 11658
Ensembl ENSG00000170017 ENSMUSG00000022636
UniProt Q13740 Q61490
RefSeq (mRNA) NM_001243280 NM_009655
RefSeq (protein) NP_001230209 NP_033785
Location (UCSC) Chr 3:
105.09 – 105.3 Mb
Chr 16:
52.25 – 52.45 Mb
PubMed search [1] [2]

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[1][2] It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently, CD166 has also been used as a potential cancer stem cell marker.


  1. ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007. 
  2. ^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". 

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