ALG1

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ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Identifiers
Symbols ALG1 ; CDG1K; HMAT1; HMT-1; HMT1; MT-1; Mat-1; hMat-1
External IDs OMIM605907 MGI2384774 HomoloGene5387 GeneCards: ALG1 Gene
EC number 2.4.1.142
Orthologs
Species Human Mouse
Entrez 56052 208211
Ensembl ENSG00000033011 ENSMUSG00000039427
UniProt Q9BT22 Q921Q3
RefSeq (mRNA) NM_019109 NM_145362
RefSeq (protein) NP_061982 NP_663337
Location (UCSC) Chr 16:
5.08 – 5.14 Mb
Chr 16:
5.23 – 5.24 Mb
PubMed search [1] [2]

Chitobiosyldiphosphodolichol beta-mannosyltransferase is an enzyme that is encoded by the ALG1 gene [1] whose structure and function has been conserved from yeast to man.[2][3]

Function[edit]

The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. The Alg1 mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.[2]

References[edit]

  1. ^ Couto JR, Huffaker TC, Robbins PW (1984). "Cloning and expression in Escherichia coli of a yeast mannosyltransferase from the asparagine-linked glycosylation pathway". J.Biol. Chem 259 (1): 378–82. PMID 6368538. 
  2. ^ a b "Entrez Gene: ALG1 asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase)". 
  3. ^ Takahashi T, Honda R, Nishikawa Y (Mar 2000). "Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1". Glycobiology 10 (3): 321–7. doi:10.1093/glycob/10.3.321. PMID 10704531. 

Further reading[edit]

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