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ALG2, alpha-1,3/1,6-mannosyltransferase
Symbols ALG2 ; CDGIi; NET38; hALPG2
External IDs OMIM607905 MGI1914731 HomoloGene5930 GeneCards: ALG2 Gene
EC number,
Species Human Mouse
Entrez 85365 56737
Ensembl ENSG00000119523 ENSMUSG00000039740
UniProt Q9H553 Q9DBE8
RefSeq (mRNA) NM_033087 NM_019998
RefSeq (protein) NP_149078 NP_064382
Location (UCSC) Chr 9:
101.98 – 101.98 Mb
Chr 4:
47.47 – 47.47 Mb
PubMed search [1] [2]

Alpha-1,3-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene.[1] Mutations in the human gene are associated with congenital defects in glycosylation [1][2]

This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).[2]


ALG2 has been shown to interact with ANXA7[3] and ANXA11.[3]


  1. ^ a b Jackson BJ, Kukuruzinska MA, Robbins P. (Jun 1993). "Biosynthesis of asparagine-linked oligosaccharides in Saccharomyces cerevisiae: the alg2 mutation.". Glycobiology. 3(4):357-64. 3 (4): 357–64. doi:10.1074/jbc.M302850200. PMID 12684507. 
  2. ^ a b "Entrez Gene: ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)". 
  3. ^ a b Satoh, Hirokazu; Nakano Yoshimi; Shibata Hideki; Maki Masatoshi (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochim. Biophys. Acta (Netherlands) 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. ISSN 0006-3002. PMID 12445460. 

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