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Additional ALK inhibitors currently (or soon to be) undergoing clinical trials include:
- Brigatinib (AP26113 by Ariad) (breakthrough status in U.S.)
- Entrectinib (Nerviano's NMS-E628, licensed by Ignyta and renamed RXDX-101, in the U.S. orphan drug designation and rare pediatric disease designation for the treatment of neuroblastoma and orphan drug designation for treatment of TrkA-, TrkB-, TrkC-, ROS1- and ALK-positive NSCLC)
- PF-06463922 (Pfizer)
- TSR-011 (Tesaro)
- CEP-37440 (Teva)
- X-396 (Xcovery)
Updates for several of these will be available at the start of June at ASCO 2014.
- Nelsen (2010). "ALK Inhibitors: Possible New Treatment for Lung Cancer".
- Farmer (2010). "Non-Small-Cell Lung Cancer Standards of Care Challenged by a Cornucopia of New Drugs".
- Chustecka (2010). "Crizotinib in ALK-NSCLC; Response Rate "Unprecedented"".
- "FDA Approves Ceritinib for ALK-Positive Lung Cancer". Medscape. April 29, 2014.
- Galkin et al. (2007). "Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK".