ALOX15

Arachidonate 15-lipoxygenase
Available structures PDB 2ABT
Identifiers
Symbols	ALOX15; 15-LOX-1; 15LOX-1
External IDs	OMIM: 152392 MGI: 87997 HomoloGene: 44935 GeneCards: ALOX15 Gene
EC number	1.13.11.33
Gene Ontology Molecular function • arachidonate 12-lipoxygenase activity • iron ion binding • lipoxygenase activity • oxidoreductase activity • metal ion binding • hepoxilin-epoxide hydrolase activity • arachidonate 15-lipoxygenase activity Cellular component • nucleus • nucleolus • cytoplasm • cytosol Biological process • lipid metabolic process • inflammatory response • leukotriene biosynthetic process • lipoxygenase pathway • bone mineralization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	246	11687
Ensembl	ENSG00000161905	ENSMUSG00000018924
UniProt	P16050	P39654
RefSeq (mRNA)	NM_001140.3	NM_009660.3
RefSeq (protein)	NP_001131.3	NP_033790.3
Location (UCSC)	Chr 17: 4.53 – 4.55 Mb	Chr 11: 70.16 – 70.17 Mb
PubMed search	[1]	[2]

Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene.

Further reading

• Kelavkar U, Glasgow W, Eling TE (2003). "The effect of 15-lipoxygenase-1 expression on cancer cells". Current urology reports 3 (3): 207–14. doi:10.1007/s11934-002-0066-8. PMID 12084190. 
• Sigal E, Dicharry S, Highland E, Finkbeiner WE (1992). "Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium". Am. J. Physiol. 262 (4 Pt 1): L392–8. PMID 1566855. 
• Izumi T, Rådmark O, Jörnvall H, Samuelsson B (1992). "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes". Eur. J. Biochem. 202 (3): 1231–8. doi:10.1111/j.1432-1033.1991.tb16495.x. PMID 1662607. 
• Conrad DJ, Kuhn H, Mulkins M et al (1992). "Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 217–21. doi:10.1073/pnas.89.1.217. PMC 48207. PMID 1729692. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48207. 
• Lei ZM, Rao CV (1992). "The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria". Endocrinology 130 (2): 861–70. doi:10.1210/en.130.2.861. PMID 1733732. 
• Izumi T, Rådmark O, Samuelsson B (1991). "Purification of 15-lipoxygenase from human leukocytes, evidence for the presence of isozymes". Adv. Prostaglandin Thromboxane Leukot. Res. 21A: 101–4. PMID 1825526. 
• Sloane DL, Leung R, Craik CS, Sigal E (1991). "A primary determinant for lipoxygenase positional specificity". Nature 354 (6349): 149–52. doi:10.1038/354149a0. PMID 1944593. 
• Nadel JA, Conrad DJ, Ueki IF et al (1991). "Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells". J. Clin. Invest. 87 (4): 1139–45. doi:10.1172/JCI115110. PMC 295116. PMID 2010530. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=295116. 
• Kroschwald P, Kroschwald A, Kühn H et al (1989). "Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes". Biochem. Biophys. Res. Commun. 160 (2): 954–60. doi:10.1016/0006-291X(89)92528-X. PMID 2719708. 
• Sigal E, Nadel JA (1989). "Arachidonic acid 15-lipoxygenase and airway epithelium. Biologic effects and enzyme purification". Am. Rev. Respir. Dis. 138 (6 Pt 2): S35–40. PMID 3202520. 
• Sigal E, Craik CS, Highland E et al (1989). "Molecular cloning and primary structure of human 15-lipoxygenase". Biochem. Biophys. Res. Commun. 157 (2): 457–64. doi:10.1016/S0006-291X(88)80271-7. PMID 3202857. 
• Sigal E, Grunberger D, Craik CS et al (1988). "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases". J. Biol. Chem. 263 (11): 5328–32. PMID 3356688. 
• Nassar GM, Morrow JD, Roberts LJ et al (1994). "Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes". J. Biol. Chem. 269 (44): 27631–4. PMID 7961680. 
• Kritzik MR, Ziober AF, Dicharry S et al (1997). "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene". Biochim. Biophys. Acta 1352 (3): 267–81. PMID 9224951. 
• Brinckmann R, Schnurr K, Heydeck D et al (1998). "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme". Blood 91 (1): 64–74. PMID 9414270. 
• Kelavkar U, Wang S, Montero A et al (1998). "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes". Mol. Biol. Rep. 25 (3): 173–82. doi:10.1023/A:1006813009006. PMID 9700053. 
• Roy B, Cathcart MK (1998). "Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes". J. Biol. Chem. 273 (48): 32023–9. doi:10.1074/jbc.273.48.32023. PMID 9822675. 
• Kratky D, Lass A, Abuja PM et al (1999). "A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates". Biochim. Biophys. Acta 1437 (1): 13–22. PMID 9931410. 
• Kelavkar UP, Badr KF (1999). "Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4378–83. doi:10.1073/pnas.96.8.4378. PMC 16340. PMID 10200270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16340.