From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arachidonate 15-lipoxygenase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ALOX15 ; 12-LOX; 15-LOX-1; 15LOX-1
External IDs OMIM152392 MGI87997 HomoloGene44935 IUPHAR: 1388 ChEMBL: 2903 GeneCards: ALOX15 Gene
EC number,
RNA expression pattern
PBB GE ALOX15 207328 at tn.png
More reference expression data
Species Human Mouse
Entrez 246 11687
Ensembl ENSG00000161905 ENSMUSG00000018924
UniProt P16050 P39654
RefSeq (mRNA) NM_001140 NM_009660
RefSeq (protein) NP_001131 NP_033790
Location (UCSC) Chr 17:
4.53 – 4.55 Mb
Chr 11:
70.34 – 70.35 Mb
PubMed search [1] [2]

Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene.[1] ALOX15, also termed 15-lipoxygenase-1 (15-LO-1 or 15-LOX-1), is distinguished from its related oxygenase, ALOX15B or 15-lipoxygenase-2. ALOX15 oxygenates arachidonic acid at either its 15 or 12 carbon position to form respectively 15-hydroperoxyicosatetraenoic acid and 12-hydroperoxyicosatetraenoic acid. 15-hydroperoxyicosatetraenoic (see 15-hydroxyicosatetraenoic acid) and 12-hydroperoxyicosatetraenoic (see 12-Hydroxyeicosatetraenoic acid) acids have intrinsic, biologically and medically significant bioactivities but are also further metabolized to a wide range of products whose activities extend far beyond their precursors.


  1. ^ Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America 89 (9): 3962–6. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320. 

Further reading[edit]