ALOX15B

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Arachidonate 15-lipoxygenase, type B
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ALOX15B ; 15-LOX-2
External IDs OMIM603697 MGI1098228 HomoloGene886 ChEMBL: 2457 GeneCards: ALOX15B Gene
EC number 1.13.11.33
RNA expression pattern
PBB GE ALOX15B 206714 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 247 11688
Ensembl ENSG00000179593 ENSMUSG00000020891
UniProt O15296 O35936
RefSeq (mRNA) NM_001039130 NM_009661
RefSeq (protein) NP_001034219 NP_033791
Location (UCSC) Chr 17:
7.94 – 7.95 Mb
Chr 11:
69.18 – 69.2 Mb
PubMed search [1] [2]

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[1][2]

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

References[edit]

  1. ^ Brash AR, Boeglin WE, Chang MS (Jul 1997). "Discovery of a second 15S-lipoxygenase in humans". Proc Natl Acad Sci U S A 94 (12): 6148–52. doi:10.1073/pnas.94.12.6148. PMC 21017. PMID 9177185. 
  2. ^ a b "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B". 

Further reading[edit]