AM-905

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AM-905
AM-905.svg
Systematic (IUPAC) name
(6aR,9R,10aR)-3-[(E)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Clinical data
Legal status ?
Identifiers
CAS number  YesY
ATC code ?
PubChem CID 9998522
ChemSpider 8174103 YesY
ChEMBL CHEMBL127848 YesY
Chemical data
Formula C23H34O3 
Mol. mass 358.513 g/mol
 YesY (what is this?)  (verify)

AM-905 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2nM at CB1 and 5.3nM at CB2.[1]

References[edit]

  1. ^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219