AM-906

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AM-906
AM-906.svg
Systematic (IUPAC) name
(6aR,9R,10aR)-3-[(Z)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Clinical data
Legal status ?
Identifiers
CAS number  YesY
ATC code ?
PubChem CID 10089808
ChemSpider 8174103 YesY
ChEMBL CHEMBL127848 YesY
Chemical data
Formula C23H34O3 
Mol. mass 358.513 g/mol
 YesY (what is this?)  (verify)

AM-906 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.8nM at CB1 and 9.5nM at CB2, a selectivity of almost 12x.[1]

See also[edit]

References[edit]

  1. ^ Papahatjis DP, et al. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219