AMG-36

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AMG-36
AMG-36.png
Systematic (IUPAC) name
(6aR,10aR)-3-(1-hexylcyclopentyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Clinical data
Legal status
?
Identifiers
ATC code ?
PubChem CID 10982174
ChemSpider 9157375 YesY
ChEMBL CHEMBL108868 YesY
Chemical data
Formula C27H40O2 
Mol. mass 396.604 g/mol
 YesY (what is this?)  (verify)

AMG-36 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.4nM at CB1 vs 1.9nM at CB2.[1][2]

References[edit]

  1. ^ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
  2. ^ Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444