AMG-41

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AMG-41
AMG-41.svg
Systematic (IUPAC) name
(6aR,10aR)-3-(1-hexylcyclopropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Clinical data
Legal status
?
Identifiers
ATC code ?
PubChem CID 10361702
ChemSpider 8537151 YesY
ChEMBL CHEMBL19847 YesY
Chemical data
Formula C25H36O2 
Mol. mass 368.551 g/mol
 YesY (what is this?)  (verify)

AMG-41 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.4nM at CB1 vs 0.9nM at CB2.[1][2][3]

References[edit]

  1. ^ Papahatjis DP, Nikas SP, Andreou T, Makriyannis A. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic and Medicinal Chemistry Letters. 2002 Dec 16;12(24):3583-6. PMID 12443781
  2. ^ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
  3. ^ Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444