AMPA

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For the degradation product of glyphosphate also known as AMPA, see aminomethylphosphonic acid.
For the U.S. LGBT advocacy and support group, see The American Military Partner Association.
AMPA
AMPA.svg
Names
IUPAC name
2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
Identifiers
74341-63-2 N
ChEMBL ChEMBL276815 N
ChemSpider 1184 YesY
DrugBank DB02057 YesY
Jmol-3D images Image
KEGG C11033 YesY
MeSH AMPA
PubChem 1221
Properties
C7H10N2O4
Molar mass 186.17 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.[1]

There are several types of glutamatergic ion channels in the central nervous system including AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.[2] AMPA generates fast excitatory postsynaptic potentials (EPSP).[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.

See also[edit]

References[edit]

  1. ^ a b Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7. 
  2. ^ Dinh, L; Nguyen T; Salgado H; Atzori M (2009). "Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat". Neurochem Res 34 (11): 1896–906. doi:10.1007/s11064-009-9966-z. PMID 19357950.