AMY2A

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Amylase, alpha 2A (pancreatic)
Protein AMY2A PDB 1b2y.png
PDB rendering based on 1b2y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AMY2A ; AMY2; AMY2B; PA
External IDs OMIM104650 MGI88019 HomoloGene20179 ChEMBL: 2045 GeneCards: AMY2A Gene
EC number 3.2.1.1
Orthologs
Species Human Mouse
Entrez 279 11722
Ensembl ENSG00000243480 ENSMUSG00000074264
UniProt P04746 P00687
RefSeq (mRNA) NM_000699 NM_001110505
RefSeq (protein) NP_000690 NP_001103975
Location (UCSC) Chr 1:
104.16 – 104.17 Mb
Chr 3:
113.56 – 113.61 Mb
PubMed search [1] [2]

Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene.[1][2]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[2]

References[edit]

  1. ^ Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (Jul 1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Res 16 (10): 4724. doi:10.1093/nar/16.10.4724. PMC 336663. PMID 3260028. 
  2. ^ a b "Entrez Gene: AMY2A amylase, alpha 2A; pancreatic". 

Further reading[edit]