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Anaphase promoting complex subunit 5
Symbols ANAPC5 ; APC5
External IDs OMIM606948 MGI1929722 HomoloGene41118 GeneCards: ANAPC5 Gene
RNA expression pattern
PBB GE ANAPC5 208721 s at tn.png
PBB GE ANAPC5 208722 s at tn.png
PBB GE ANAPC5 211036 x at tn.png
More reference expression data
Species Human Mouse
Entrez 51433 59008
Ensembl ENSG00000089053 ENSMUSG00000029472
UniProt Q9UJX4 Q8BTZ4
RefSeq (mRNA) NM_001137559 NM_001042491
RefSeq (protein) NP_001131031 NP_001035956
Location (UCSC) Chr 12:
121.75 – 121.84 Mb
Chr 5:
122.79 – 122.82 Mb
PubMed search [1] [2]

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.[1][2]

The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM][2]


ANAPC5 has been shown to interact with ANAPC1,[3][4] ANAPC4,[3] CDC27[3][5][6] and PABPC1.[5]


  1. ^ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science 279 (5354): 1219–22. doi:10.1126/science.279.5354.1219. PMID 9469815. 
  2. ^ a b "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5". 
  3. ^ a b c Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. (England) 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. 
  4. ^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. (UNITED STATES) 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961. 
  5. ^ a b Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. (United States) 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755. 
  6. ^ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056. 

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