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Angiopoietin-like 3
Symbols ANGPTL3 ; ANG-5; ANGPT5; ANL3; FHBL2
External IDs OMIM604774 MGI1353627 HomoloGene8499 GeneCards: ANGPTL3 Gene
RNA expression pattern
PBB GE ANGPTL3 219803 at tn.png
More reference expression data
Species Human Mouse
Entrez 27329 30924
Ensembl ENSG00000132855 ENSMUSG00000028553
UniProt Q9Y5C1 Q9R182
RefSeq (mRNA) NM_014495 NM_013913
RefSeq (protein) NP_055310 NP_038941
Location (UCSC) Chr 1:
63.06 – 63.07 Mb
Chr 4:
99.03 – 99.05 Mb
PubMed search [1] [2]

Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene.[1][2]


The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.[1]

Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-rich HDL particles have high cholesterol efflux abilities.

Clinical significance[edit]

In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.

In humans with genetic loss-of-function variants in one copy of ANGPTL3, the serum LDL-C levels are reduced. In those with loss-of-function variants in both copies of ANGPTL3, low LDL-C, low HDL-C, and low triglycerides are seen ("familial combined hypolipidemia").[3]


  1. ^ a b "Entrez Gene: ANGPTL3 angiopoietin-like 3". 
  2. ^ Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB (December 1999). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver". Genomics 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446. 
  3. ^ Musunuru K, Pirruccello JP, Do R, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J et al. (2010). "Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia". New England Journal of Medicine 363 (23): 2220–2227. doi:10.1056/NEJMoa1002926. PMC 3008575. PMID 20942659.   edit

Further reading[edit]