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KN motif and ankyrin repeat domains 1
Symbols KANK1 ; ANKRD15; CPSQ2; KANK
External IDs OMIM607704 MGI2147707 HomoloGene17706 GeneCards: KANK1 Gene
RNA expression pattern
PBB GE ANKRD15 213005 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23189 107351
Ensembl ENSG00000107104 ENSMUSG00000032702
UniProt Q14678 E9Q238
RefSeq (mRNA) NM_001256876 NM_181404
RefSeq (protein) NP_001243805 NP_852069
Location (UCSC) Chr 9:
0.47 – 0.75 Mb
Chr 19:
25.24 – 25.43 Mb
PubMed search [1] [2]

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.[1][2][3]

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma.

Two alternatively spliced transcript variants encoding different isoforms have been identified.[3]


  1. ^ Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830. 
  2. ^ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375. 
  3. ^ a b "Entrez Gene: ANKRD15 ankyrin repeat domain 15". 

Further reading[edit]