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Ankyrin repeat domain 2 (stretch responsive muscle)
Symbols ANKRD2 ; ARPP
External IDs OMIM610734 MGI1861447 HomoloGene10568 GeneCards: ANKRD2 Gene
RNA expression pattern
PBB GE ANKRD2 221232 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26287 56642
Ensembl ENSG00000165887 ENSMUSG00000025172
UniProt Q9GZV1 Q9WV06
RefSeq (mRNA) NM_001129981 NM_020033
RefSeq (protein) NP_001123453 NP_064417
Location (UCSC) Chr 10:
99.33 – 99.34 Mb
Chr 19:
42.04 – 42.05 Mb
PubMed search [1] [2]

Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene.[1][2][3][4]


ANKRD2 has been shown to interact with Y box binding protein 1,[2] Telethonin,[2] Promyelocytic leukemia protein[2] and P53.[2]


  1. ^ Kemp TJ, Sadusky TJ, Saltisi F, Carey N, Moss J, Yang SY, Sassoon DA, Goldspink G, Coulton GR (Sep 2000). "Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein". Genomics 66 (3): 229–41. doi:10.1006/geno.2000.6213. PMID 10873377. 
  2. ^ a b c d e Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (May 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J Mol Biol 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035. 
  3. ^ Mckoy G, Hou Y, Yang SY, Vega Avelaira D, Degens H, Goldspink G, Coulton GR (May 2005). "Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function". J Appl Physiol 98 (6): 2337–43; discussion 2320. doi:10.1152/japplphysiol.01046.2004. PMID 15677738. 
  4. ^ "Entrez Gene: ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)". 

Further reading[edit]