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Ankyrin repeat domain 2 (stretch responsive muscle)
Symbols ANKRD2 ; ARPP
External IDs OMIM610734 MGI1861447 HomoloGene10568 GeneCards: ANKRD2 Gene
RNA expression pattern
PBB GE ANKRD2 221232 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26287 56642
Ensembl ENSG00000165887 ENSMUSG00000025172
UniProt Q9GZV1 Q9WV06
RefSeq (mRNA) NM_001129981 NM_020033
RefSeq (protein) NP_001123453 NP_064417
Location (UCSC) Chr 10:
99.33 – 99.34 Mb
Chr 19:
42.04 – 42.05 Mb
PubMed search [1] [2]

Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene.[1][2][3][4]


ANKRD2 has been shown to interact with Y box binding protein 1,[2] Telethonin,[2] Promyelocytic leukemia protein[2] and P53.[2]


  1. ^ Kemp TJ, Sadusky TJ, Saltisi F, Carey N, Moss J, Yang SY et al. (Sep 2000). "Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein". Genomics 66 (3): 229–41. doi:10.1006/geno.2000.6213. PMID 10873377. 
  2. ^ a b c d e Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V et al. (May 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035. 
  3. ^ Mckoy G, Hou Y, Yang SY, Vega Avelaira D, Degens H, Goldspink G et al. (May 2005). "Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function". J. Appl. Physiol. 98 (6): 2337–43; discussion 2320. doi:10.1152/japplphysiol.01046.2004. PMID 15677738. 
  4. ^ "Entrez Gene: ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)". 

Further reading[edit]

  • Sosovec V, Ivicic L, Gaspar I, L'Achová B (1975). "[Incidence of benign conjugated hyperbilirubinemia with pigment in the liver in Spis (Dubin-Johnson syndrome) II. Attempts at screening of carrier state by means of BSP test]". Cesk Gastroenterol Vyz 29 (8): 517–26. PMID 1204005. 
  • Pallavicini A, Kojić S, Bean C, Vainzof M, Salamon M, Ievolella C et al. (2001). "Characterization of human skeletal muscle Ankrd2". Biochem. Biophys. Res. Commun. 285 (2): 378–86. doi:10.1006/bbrc.2001.5131. PMID 11444853. 
  • Moriyama M, Tsukamoto Y, Fujiwara M, Kondo G, Nakada C, Baba T et al. (2001). "Identification of a novel human ankyrin-repeated protein homologous to CARP". Biochem. Biophys. Res. Commun. 285 (3): 715–23. doi:10.1006/bbrc.2001.5216. PMID 11453652. 
  • Laveder P, De Pittà C, Toppo S, Valle G, Lanfranchi G (2002). "A two-step strategy for constructing specifically self-subtracted cDNA libraries". Nucleic Acids Res. 30 (9): e38. doi:10.1093/nar/30.9.e38. PMC 113861. PMID 11972353. 
  • Tsukamoto Y, Senda T, Nakano T, Nakada C, Hida T, Ishiguro N et al. (2002). "Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation". Lab. Invest. 82 (5): 645–55. doi:10.1038/labinvest.3780459. PMID 12004005. 
  • Nakamura K, Nakada C, Takeuchi K, Osaki M, Shomori K, Kato S et al. (2003). "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis". Pathobiology 70 (4): 197–203. doi:10.1159/000069329. PMID 12679596. 
  • Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K et al. (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. PMID 14583192. 
  • Ishiguro N, Motoi T, Osaki M, Araki N, Minamizaki T, Moriyama M et al. (2005). "Immunohistochemical analysis of a muscle ankyrin-repeat protein, Arpp, in paraffin-embedded tumors: evaluation of Arpp as a tumor marker for rhabdomyosarcoma". Hum. Pathol. 36 (6): 620–5. doi:10.1016/j.humpath.2005.04.014. PMID 16021567. 
  • Shomori K, Nagashima Y, Kuroda N, Honjo A, Tsukamoto Y, Tokuyasu N et al. (2007). "ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas". Mod. Pathol. 20 (2): 199–207. doi:10.1038/modpathol.3800730. PMID 17206105.