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Anillin, actin binding protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ANLN ; Scraps; scra
External IDs MGI1920174 HomoloGene41281 GeneCards: ANLN Gene
RNA expression pattern
PBB GE ANLN gnf1h00312 at tn.png
More reference expression data
Species Human Mouse
Entrez 54443 68743
Ensembl ENSG00000011426 ENSMUSG00000036777
UniProt Q9NQW6 Q8K298
RefSeq (mRNA) NM_001284301 NM_028390
RefSeq (protein) NP_001271230 NP_082666
Location (UCSC) Chr 7:
36.39 – 36.45 Mb
Chr 9:
22.33 – 22.39 Mb
PubMed search [1] [2]

Actin-binding protein anillin is a protein that in humans is encoded by the ANLN gene.[1][2] It is a 124 kDa scaffolding protein involved in cytokinesis. It is found in high concentrations near the cleavage furrow and coincides with RhoA, the key regulator of contractile-ring formation.[3]


At the N-terminus, there is an actin and myosin binding domain; at the C terminus, there is a PH domain, which is conserved and is essential for its function.[3] Anillin is highly enriched and abundant in metazoan cleavage furrows and provides an excellent cytological marker.[4]


  1. ^ Oegema K, Savoian MS, Mitchison TJ, Field CM (Sep 2000). "Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis". J Cell Biol 150 (3): 539–52. doi:10.1083/jcb.150.3.539. PMC 2175195. PMID 10931866. 
  2. ^ "Entrez Gene: ANLN anillin, actin binding protein". 
  3. ^ a b Piekny, AJ; Glotzer, M (2008). "Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis". Current biology : CB 18 (1): 30–6. doi:10.1016/j.cub.2007.11.068. PMID 18158243. 
  4. ^ The myriad roles of Anillin during cytokinesis. Piekny AJ, Maddox AS. Semin Cell Dev Biol. 2010 Dec;21(9):881-91.

Further reading[edit]