ANLN

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Anillin, actin binding protein
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANLN ; Scraps; scra
External IDs MGI1920174 HomoloGene41281 GeneCards: ANLN Gene
RNA expression pattern
PBB GE ANLN gnf1h00312 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54443 68743
Ensembl ENSG00000011426 ENSMUSG00000036777
UniProt Q9NQW6 Q8K298
RefSeq (mRNA) NM_001284301 NM_028390
RefSeq (protein) NP_001271230 NP_082666
Location (UCSC) Chr 7:
36.39 – 36.45 Mb
Chr 9:
22.33 – 22.39 Mb
PubMed search [1] [2]

Actin-binding protein anillin is a protein that in humans is encoded by the ANLN gene.[1][2] It is a 124 kDa scaffolding protein involved in cytokinesis. It is found in high concentrations near the cleavage furrow and coincides with RhoA, the key regulator of contractile-ring formation.[3]

Structure[edit]

At the N-terminus, there is an actin and myosin binding domain; at the C terminus, there is a PH domain, which is conserved and is essential for its function.[3] Anillin is highly enriched and abundant in metazoan cleavage furrows and provides an excellent cytological marker.[4]

References[edit]

  1. ^ Oegema K, Savoian MS, Mitchison TJ, Field CM (Sep 2000). "Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis". J Cell Biol 150 (3): 539–52. doi:10.1083/jcb.150.3.539. PMC 2175195. PMID 10931866. 
  2. ^ "Entrez Gene: ANLN anillin, actin binding protein". 
  3. ^ a b Piekny, AJ; Glotzer, M (2008). "Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis". Current biology : CB 18 (1): 30–6. doi:10.1016/j.cub.2007.11.068. PMID 18158243. 
  4. ^ The myriad roles of Anillin during cytokinesis. Piekny AJ, Maddox AS. Semin Cell Dev Biol. 2010 Dec;21(9):881-91.

Further reading[edit]