ANTXR1

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Anthrax toxin receptor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANTXR1 ; ATR; TEM8
External IDs OMIM606410 MGI1916788 HomoloGene12976 GeneCards: ANTXR1 Gene
RNA expression pattern
PBB GE ANTXR1 220092 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84168 69538
Ensembl ENSG00000169604 ENSMUSG00000033420
UniProt Q9H6X2 Q9CZ52
RefSeq (mRNA) NM_018153 NM_054041
RefSeq (protein) NP_060623 NP_473382
Location (UCSC) Chr 2:
69.24 – 69.48 Mb
Chr 6:
87.13 – 87.34 Mb
PubMed search [1] [2]

Anthrax toxin receptor 1 is a protein that in humans is encoded by the ANTXR1 gene.[1][2][3]

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.[3]

See also[edit]

References[edit]

  1. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  2. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res 61 (18): 6649–55. PMID 11559528. 
  3. ^ a b "Entrez Gene: ANTXR1 anthrax toxin receptor 1". 

Further reading[edit]