AP1B1

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Adaptor-related protein complex 1, beta 1 subunit
PDB 1w63 EBI.jpg
Rendering of AP1B1 from PDB 1w63
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AP1B1 ; ADTB1; AP105A; BAM22; CLAPB2
External IDs OMIM600157 MGI1096368 HomoloGene21972 GeneCards: AP1B1 Gene
RNA expression pattern
PBB GE AP1B1 205423 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 162 11764
Ensembl ENSG00000100280 ENSMUSG00000009090
UniProt Q10567 O35643
RefSeq (mRNA) NM_001127 NM_001243043
RefSeq (protein) NP_001118 NP_001229972
Location (UCSC) Chr 22:
29.72 – 29.82 Mb
Chr 11:
4.99 – 5.04 Mb
PubMed search [1] [2]

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.[1][2][3]

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.[3]

Interactions[edit]

AP1B1 has been shown to interact with KIF13A[4] and AP1G1.[5][6][7]

References[edit]

  1. ^ Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet 3 (8): 1393–9. doi:10.1093/hmg/3.8.1393. PMID 7987321. 
  2. ^ Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID 8812422. 
  3. ^ a b "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". 
  4. ^ Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell (UNITED STATES) 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. ISSN 0092-8674. PMID 11106728. 
  5. ^ Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. (UNITED STATES) 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. ISSN 0021-9258. PMID 9733768. 
  6. ^ Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737. 
  7. ^ Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184. 

Further reading[edit]