From Wikipedia, the free encyclopedia
Jump to: navigation, search
Adaptor-related protein complex 1, gamma 1 subunit
Protein AP1G1 PDB 1gyu.png
PDB rendering based on 1gyu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP1G1 ; ADTG; CLAPG1
External IDs OMIM603533 MGI101919 HomoloGene47995 GeneCards: AP1G1 Gene
RNA expression pattern
PBB GE AP1G1 203350 at tn.png
More reference expression data
Species Human Mouse
Entrez 164 11765
Ensembl ENSG00000166747 ENSMUSG00000031731
UniProt O43747 P22892
RefSeq (mRNA) NM_001030007 NM_001301211
RefSeq (protein) NP_001025178 NP_001288140
Location (UCSC) Chr 16:
71.76 – 71.84 Mb
Chr 8:
109.78 – 109.86 Mb
PubMed search [1] [2]

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.[1][2]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.[3]


AP1G1 has been shown to interact with RABEP1,[4][5] AP1B1,[2][6][7] Synaptophysin,[8] AP1M1,[6][7] NECAP2,[9] AP1S1[2][6][7] and AP1GBP1.[4][10]


  1. ^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlen S, Dumanski JP (October 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655. 
  2. ^ a b c Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (October 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768. 
  3. ^ "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". 
  4. ^ a b Nogi, Terukazu; Shiba Yoko, Kawasaki Masato, Shiba Tomoo, Matsugaki Naohiro, Igarashi Noriyuki, Suzuki Mamoru, Kato Ryuichi, Takatsu Hiroyuki, Nakayama Kazuhisa, Wakatsuki Soichi (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. (United States) 9 (7): 527–31. doi:10.1038/nsb808. ISSN 1072-8368. PMID 12042876. 
  5. ^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5–Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986. 
  6. ^ a b c Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737. 
  7. ^ a b c Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184. 
  8. ^ Horikawa, Hiroshi P M; Kneussel Matthias; El Far Oussama; Betz Heinrich (November 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Mol. Cell. Neurosci. (United States) 21 (3): 454–62. doi:10.1006/mcne.2002.1191. ISSN 1044-7431. PMID 12498786. 
  9. ^ Mattera, Rafael; Ritter Brigitte; Sidhu Sachdev S; McPherson Peter S; Bonifacino Juan S (February 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. (United States) 279 (9): 8018–28. doi:10.1074/jbc.M311873200. ISSN 0021-9258. PMID 14665628. 
  10. ^ Takatsu, H; Yoshino K; Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. (UNITED STATES) 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. ISSN 0006-291X. PMID 10814529. 

Further reading[edit]