AP1GBP1

Synergin, gamma
Identifiers
Symbols	SYNRG; AP1GBP1; FLJ34482; MGC104959; SYNG
External IDs	OMIM: 607291 MGI: 1354742 HomoloGene: 105680 GeneCards: SYNRG Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • cytoplasm • Golgi apparatus • membrane • AP-1 adaptor complex Biological process • intracellular protein transport • endocytosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11276	217030
Ensembl	ENSG00000006114	ENSMUSG00000034940
UniProt	Q9UMZ2	Q5SV85
RefSeq (mRNA)	NM_001163544.1	NM_194341
RefSeq (protein)	NP_001157016.1	NP_919322
Location (UCSC)	Chr 17: 35.87 – 35.97 Mb	Chr 11: 83.78 – 83.86 Mb
PubMed search	[1]	[2]

AP1 subunit gamma-binding protein 1 is a protein that in humans is encoded by the SYNRG gene.

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Interactions

AP1GBP1 has been shown to interact with AP1G1 and SCAMP1.

Further reading

• Peyrard M, Parveneh S, Lagercrantz S, et al. (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655. 
• Hirst J, Lui WW, Bright NA, et al. (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J. Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175106. 
• Fernández-Chacón R, Achiriloaie M, Janz R, et al. (2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571. 
• Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529. 
• Nogi T, Shiba Y, Kawasaki M, et al. (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. 
• Kent HM, McMahon HT, Evans PR, et al. (2003). "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin". Structure 10 (8): 1139–48. doi:10.1016/S0969-2126(02)00801-8. PMID 12176391. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172650. 
• Lui WW, Collins BM, Hirst J, et al. (2004). "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin". Mol. Biol. Cell 14 (6): 2385–98. doi:10.1091/mbc.E02-11-0735. PMC 194887. PMID 12808037. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=194887. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hirst J, Borner GH, Harbour M, Robinson MS (2005). "The aftiphilin/p200/gamma-synergin complex". Mol. Biol. Cell 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1087257. 
• Theos AC, Tenza D, Martina JA, et al. (2006). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Mol. Biol. Cell 16 (11): 5356–72. doi:10.1091/mbc.E05-07-0626. PMC 1266432. PMID 16162817. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1266432.