AP1M1

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Adaptor-related protein complex 1, mu 1 subunit
PBB Protein AP1M1 image.jpg
PDB rendering based on 1w63.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AP1M1 ; AP47; CLAPM2; CLTNM; MU-1A
External IDs OMIM603535 MGI102776 HomoloGene4017 GeneCards: AP1M1 Gene
RNA expression pattern
PBB GE AP1M1 gnf1h00787 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8907 11767
Ensembl ENSG00000072958 ENSMUSG00000003033
UniProt Q9BXS5 P35585
RefSeq (mRNA) NM_001130524 NM_007456
RefSeq (protein) NP_001123996 NP_031482
Location (UCSC) Chr 19:
16.31 – 16.35 Mb
Chr 8:
72.24 – 72.26 Mb
PubMed search [1] [2]

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.[1][2]

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.[3]

Interactions[edit]

AP1M1 has been shown to interact with VAMP4[4] and AP1G1.[5][6]

References[edit]

  1. ^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlen S, Dumanski JP (Oct 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655. 
  2. ^ Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Dec 2007). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin". Traffic 9 (1): 121–32. doi:10.1111/j.1600-0854.2007.00672.x. PMID 17988225. 
  3. ^ "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". 
  4. ^ Hinners, Ina; Wendler Franz; Fei Hao; Thomas Laurel; Thomas Gary; Tooze Sharon A (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep. (England) 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. ISSN 1469-221X. PMC 1326413. PMID 14608369. 
  5. ^ Fölsch, H; Ohno H; Bonifacino J S; Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737. 
  6. ^ Page, L J; Robinson M S (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184. 

Further reading[edit]