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Adaptor-related protein complex 1, mu 1 subunit
PBB Protein AP1M1 image.jpg
PDB rendering based on 1w63.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP1M1 ; AP47; CLAPM2; CLTNM; MU-1A
External IDs OMIM603535 MGI102776 HomoloGene4017 GeneCards: AP1M1 Gene
RNA expression pattern
PBB GE AP1M1 gnf1h00787 at tn.png
More reference expression data
Species Human Mouse
Entrez 8907 11767
Ensembl ENSG00000072958 ENSMUSG00000003033
UniProt Q9BXS5 P35585
RefSeq (mRNA) NM_001130524 NM_007456
RefSeq (protein) NP_001123996 NP_031482
Location (UCSC) Chr 19:
16.2 – 16.25 Mb
Chr 8:
72.24 – 72.26 Mb
PubMed search [1] [2]

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.[1][2]

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.[3]


AP1M1 has been shown to interact with VAMP4[4] and AP1G1.[5][6]


  1. ^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlen S, Dumanski JP (Oct 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655. 
  2. ^ Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Dec 2007). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin". Traffic 9 (1): 121–32. doi:10.1111/j.1600-0854.2007.00672.x. PMID 17988225. 
  3. ^ "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". 
  4. ^ Hinners, Ina; Wendler Franz; Fei Hao; Thomas Laurel; Thomas Gary; Tooze Sharon A (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep. (England) 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. ISSN 1469-221X. PMC 1326413. PMID 14608369. 
  5. ^ Fölsch, H; Ohno H; Bonifacino J S; Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737. 
  6. ^ Page, L J; Robinson M S (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184. 

Further reading[edit]