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Adaptor-related protein complex 2, alpha 2 subunit
Protein AP2A2 PDB 1b9k.png
PDB rendering based on 1b9k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP2A2 ; ADTAB; CLAPA2; HIP-9; HIP9; HYPJ
External IDs OMIM607242 MGI101920 HomoloGene5335 GeneCards: AP2A2 Gene
RNA expression pattern
PBB GE AP2A2 211779 x at tn.png
PBB GE AP2A2 212159 x at tn.png
PBB GE AP2A2 212161 at tn.png
More reference expression data
Species Human Mouse
Entrez 161 11772
Ensembl ENSG00000183020 ENSMUSG00000002957
UniProt O94973 P17427
RefSeq (mRNA) NM_001242837 NM_007459
RefSeq (protein) NP_001229766 NP_031485
Location (UCSC) Chr 11:
0.92 – 1.01 Mb
Chr 7:
141.56 – 141.63 Mb
PubMed search [1] [2]

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.[1][2][3]


AP2A2 has been shown to interact with EPN1[4] and SHC1.[5]


  1. ^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Oct 1998). "Huntingtin interacts with a family of WW domain proteins". Hum Mol Genet 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202. 
  2. ^ Robinson MS (Apr 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". J Cell Biol 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002. 
  3. ^ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". 
  4. ^ Chen, H; Fre S; Slepnev V I; Capua M R; Takei K; Butler M H; Di Fiore P P; De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature (ENGLAND) 394 (6695): 793–7. doi:10.1038/29555. ISSN 0028-0836. PMID 9723620. 
  5. ^ Okabayashi, Y; Sugimoto Y; Totty N F; Hsuan J; Kido Y; Sakaguchi K; Gout I; Waterfield M D; Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". J. Biol. Chem. (UNITED STATES) 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. ISSN 0021-9258. PMID 8617812. 

Further reading[edit]