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Adaptor-related protein complex 2, sigma 1 subunit
Protein AP2S1 PDB 1gw5.png
PDB rendering based on 1gw5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP2S1 ; AP17; CLAPS2; FBH3; FBHOk; HHC3
External IDs OMIM602242 MGI2141861 HomoloGene3001 GeneCards: AP2S1 Gene
RNA expression pattern
PBB GE AP2S1 208074 s at tn.png
PBB GE AP2S1 202120 x at tn.png
PBB GE AP2S1 211047 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1175 232910
Ensembl ENSG00000042753 ENSMUSG00000008036
UniProt P53680 P62743
RefSeq (mRNA) NM_001301076 NM_198613
RefSeq (protein) NP_001288005 NP_941015
Location (UCSC) Chr 19:
47.34 – 47.35 Mb
Chr 7:
16.74 – 16.75 Mb
PubMed search [1] [2]

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.[1][2][3]

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.[3]


  1. ^ Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778. 
  2. ^ Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099. 
  3. ^ a b "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". 

Further reading[edit]