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Adaptor-related protein complex 4, mu 1 subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AP4M1 ; CPSQ3; MU-4; MU-ARP2; SPG50
External IDs OMIM602296 MGI1337063 HomoloGene3467 GeneCards: AP4M1 Gene
RNA expression pattern
PBB GE AP4M1 209837 at tn.png
More reference expression data
Species Human Mouse
Entrez 9179 11781
Ensembl ENSG00000221838 ENSMUSG00000019518
UniProt O00189 Q9JKC7
RefSeq (mRNA) NM_004722 NM_021392
RefSeq (protein) NP_004713 NP_067367
Location (UCSC) Chr 7:
100.1 – 100.11 Mb
Chr 5:
138.17 – 138.18 Mb
PubMed search [1] [2]

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.[1][2][3]


This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.[3]


AP4M1 has been shown to interact with AP4B1.[4]

Clinical relevance[edit]

The AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[5]


  1. ^ Wang X, Kilimann MW (Feb 1997). "Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2". FEBS Lett 402 (1): 57–61. doi:10.1016/S0014-5793(96)01500-1. PMID 9013859. 
  2. ^ Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem 274 (11): 7278–85. doi:10.1074/jbc.274.11.7278. PMID 10066790. 
  3. ^ a b "Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit". 
  4. ^ Hirst J, Bright NA, Rous B, Robinson MS (August 1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell 10 (8): 2787–802. doi:10.1091/mbc.10.8.2787. PMC 25515. PMID 10436028. 
  5. ^ Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L (June 2011). "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature". Am. J. Hum. Genet. 88 (6): 788–95. doi:10.1016/j.ajhg.2011.04.019. PMC 3113253. PMID 21620353. 

Further reading[edit]