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Amyloid beta (A4) precursor protein-binding, family A, member 1
Protein APBA1 PDB 1aqc.png
PDB rendering based on 1aqc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols APBA1 ; D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA
External IDs OMIM602414 MGI1860297 HomoloGene897 GeneCards: APBA1 Gene
RNA expression pattern
PBB GE APBA1 206679 at tn.png
More reference expression data
Species Human Mouse
Entrez 320 319924
Ensembl ENSG00000107282 ENSMUSG00000024897
UniProt Q02410 B2RUJ5
RefSeq (mRNA) NM_001163 NM_177034
RefSeq (protein) NP_001154 NP_796008
Location (UCSC) Chr 9:
72.04 – 72.29 Mb
Chr 19:
23.76 – 23.95 Mb
PubMed search [1] [2]

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.[1][2][3]

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.[3]


APBA1 has been shown to interact with KCNJ12,[4][5] CCS,[6] CASK[7][8] and Amyloid precursor protein.[9][10]


  1. ^ Duclos F, Boschert U, Sirugo G, Mandel JL, Hen R, Koenig M (February 1993). "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system". Proc Natl Acad Sci U S A 90 (1): 109–13. doi:10.1073/pnas.90.1.109. PMC 45609. PMID 7678331. 
  2. ^ Duclos F, Koenig M (May 1995). "Comparison of primary structure of a neuron-specific protein, X11, between human and mouse". Mamm Genome 6 (1): 57–8. doi:10.1007/BF00350899. PMID 7719031. 
  3. ^ a b "Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)". 
  4. ^ Leonoudakis, Dmitri; Conti Lisa R; Anderson Scott; Radeke Carolyn M; McGuire Leah M M; Adams Marvin E; Froehner Stanley C; Yates John R; Vandenberg Carol A (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. (United States) 279 (21): 22331–46. doi:10.1074/jbc.M400285200. ISSN 0021-9258. PMID 15024025. 
  5. ^ Leonoudakis, Dmitri; Conti Lisa R; Radeke Carolyn M; McGuire Leah M M; Vandenberg Carol A (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. (United States) 279 (18): 19051–63. doi:10.1074/jbc.M400284200. ISSN 0021-9258. PMID 14960569. 
  6. ^ McLoughlin, D M; Standen C L; Lau K F; Ackerley S; Bartnikas T P; Gitlin J D; Miller C C (March 2001). "The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity". J. Biol. Chem. (United States) 276 (12): 9303–7. doi:10.1074/jbc.M010023200. ISSN 0021-9258. PMID 11115513. 
  7. ^ Borg, J P; Straight S W, Kaech S M, de Taddéo-Borg M, Kroon D E, Karnak D, Turner R S, Kim S K, Margolis B (November 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. (UNITED STATES) 273 (48): 31633–6. doi:10.1074/jbc.273.48.31633. ISSN 0021-9258. PMID 9822620. 
  8. ^ Borg, J P; Lõpez-Figueroa M O, de Taddèo-Borg M, Kroon D E, Turner R S, Watson S J, Margolis B (February 1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. (UNITED STATES) 19 (4): 1307–16. ISSN 0270-6474. PMID 9952408. 
  9. ^ Biederer, Thomas; Cao Xinwei; Südhof Thomas C; Liu Xinran (September 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. (United States) 22 (17): 7340–51. PMID 12196555. 
  10. ^ Borg, J P; Ooi J; Levy E; Margolis B (November 1996). "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein". Mol. Cell. Biol. (UNITED STATES) 16 (11): 6229–41. ISSN 0270-7306. PMC 231626. PMID 8887653. 

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