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N-terminal EF-hand calcium binding protein 3
Symbols NECAB3 ; APBA2BP; EFCBP3; NIP1; STIP3; SYTIP2; XB51; dJ63M2.4; dJ63M2.5
External IDs OMIM612478 MGI1861721 HomoloGene10992 GeneCards: NECAB3 Gene
RNA expression pattern
PBB GE APBA2BP 210720 s at tn.png
More reference expression data
Species Human Mouse
Entrez 63941 56846
Ensembl ENSG00000125967 ENSMUSG00000027489
UniProt Q96P71 Q9D6J4
RefSeq (mRNA) NM_031231 NM_021546
RefSeq (protein) NP_112508 NP_067521
Location (UCSC) Chr 20:
32.24 – 32.26 Mb
Chr 2:
154.54 – 154.56 Mb
PubMed search [1] [2]

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[1][2]

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[2]


  1. ^ Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507. 
  2. ^ a b "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein". 

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