Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3gene.
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
^ abTanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun255 (3): 663–7. doi:10.1006/bbrc.1999.0265. PMID10049767.
^Biederer, Thomas; Cao Xinwei; Südhof Thomas C; Liu Xinran (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. (United States) 22 (17): 7340–51. PMID12196555.
Tanahashi H, Tabira T (1999). "Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein". Neuroreport10 (12): 2575–8. doi:10.1097/00001756-199908200-00025. PMID10574372.
Okamoto M, Nakajima Y, Matsuyama T, Sugita M (2001). "Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane". Neuroscience104 (3): 653–65. doi:10.1016/S0306-4522(01)00124-5. PMID11440799.
Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV". J. Biol. Chem.279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID14990567.
Malmberg EK, Andersson CX, Gentzsch M, et al. (2005). "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3". J. Cell. Sci.117 (Pt 23): 5535–41. doi:10.1242/jcs.01472. PMID15494376.