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Amyloid beta (A4) precursor protein-binding, family A, member 3
Protein APBA3 PDB 2YT7.png
Rendering based on PDB 2YT7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols APBA3 ; MGC:15815; X11L2; mint3
External IDs OMIM604262 MGI1888527 HomoloGene3591 GeneCards: APBA3 Gene
RNA expression pattern
PBB GE APBA3 215148 s at tn.png
PBB GE APBA3 205146 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9546 57267
Ensembl ENSG00000011132 ENSMUSG00000004931
UniProt O96018 O88888
RefSeq (mRNA) NM_004886 NM_018758
RefSeq (protein) NP_004877 NP_061228
Location (UCSC) Chr 19:
3.75 – 3.76 Mb
Chr 10:
81.27 – 81.27 Mb
PubMed search [1] [2]

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.[1][2]

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.[2]


APBA3 has been shown to interact with Amyloid precursor protein.[1][3]


  1. ^ a b Tanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun 255 (3): 663–7. doi:10.1006/bbrc.1999.0265. PMID 10049767. 
  2. ^ a b "Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)". 
  3. ^ Biederer, Thomas; Cao Xinwei; Südhof Thomas C; Liu Xinran (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. (United States) 22 (17): 7340–51. PMID 12196555. 

Further reading[edit]