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Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Protein APBB1 PDB 2e45.png
PDB rendering based on 2e45.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols APBB1 ; FE65; MGC:9072; RIR
External IDs OMIM602709 MGI107765 HomoloGene898 GeneCards: APBB1 Gene
RNA expression pattern
PBB GE APBB1 202652 at tn.png
More reference expression data
Species Human Mouse
Entrez 322 11785
Ensembl ENSG00000166313 ENSMUSG00000037032
UniProt O00213 Q9QXJ1
RefSeq (mRNA) NM_001164 NM_001253885
RefSeq (protein) NP_001155 NP_001240814
Location (UCSC) Chr 11:
6.42 – 6.44 Mb
Chr 7:
105.56 – 105.57 Mb
PubMed search [1] [2]

Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.[1][2][3]

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.[3]


APBB1 has been shown to interact with APLP2,[4][5] TFCP2,[6] LRP1[7] and Amyloid precursor protein.[4][5][7][8][9]


  1. ^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346. 
  2. ^ Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM (Feb 1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum Mol Genet 5 (10): 1589–98. doi:10.1093/hmg/5.10.1589. PMID 8894693. 
  3. ^ a b "Entrez Gene: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)". 
  4. ^ a b Guénette, S Y; Chen J; Jondro P D; Tanzi R E (Oct 1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proceedings of the National Academy of Sciences of the United States of America (UNITED STATES) 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. ISSN 0027-8424. PMC 38241. PMID 8855266. 
  5. ^ a b Tanahashi, H; Tabira T (Feb 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. (IRELAND) 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. ISSN 0304-3940. PMID 10081969. 
  6. ^ Zambrano, N; Minopoli G; de Candia P; Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". J. Biol. Chem. (UNITED STATES) 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. ISSN 0021-9258. PMID 9685356. 
  7. ^ a b Trommsdorff, M; Borg J P; Margolis B; Herz J (Dec 1998). "Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". J. Biol. Chem. (UNITED STATES) 273 (50): 33556–60. doi:10.1074/jbc.273.50.33556. ISSN 0021-9258. PMID 9837937. 
  8. ^ Borg, J P; Ooi J; Levy E; Margolis B (Nov 1996). "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein". Mol. Cell. Biol. (UNITED STATES) 16 (11): 6229–41. ISSN 0270-7306. PMC 231626. PMID 8887653. 
  9. ^ Zambrano, N; Buxbaum J D, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T (Mar 1997). "Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins". J. Biol. Chem. (UNITED STATES) 272 (10): 6399–405. doi:10.1074/jbc.272.10.6399. ISSN 0021-9258. PMID 9045663. 

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