APBB1

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APBB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), FE65, MGC:9072, RIR, amyloid beta precursor protein binding family B member 1
External IDsOMIM: 602709 MGI: 107765 HomoloGene: 898 GeneCards: APBB1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253885
NM_001253886
NM_001253887
NM_009685
NM_001310600

RefSeq (protein)

NP_001240814
NP_001240815
NP_001240816
NP_001297529
NP_033815

Location (UCSC)Chr 11: 6.4 – 6.42 MbChr 7: 105.21 – 105.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.[5][6][7]

Function[edit]

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.[7]

Interactions[edit]

APBB1 has been shown to interact with APLP2,[8][9] TFCP2,[10] LRP1[11] and Amyloid precursor protein.[8][9][11][12][13]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166313 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037032 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
  6. ^ Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM (Feb 1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum Mol Genet. 5 (10): 1589–98. doi:10.1093/hmg/5.10.1589. PMID 8894693.
  7. ^ a b "Entrez Gene: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)".
  8. ^ a b Guénette SY, Chen J, Jondro PD, Tanzi RE (Oct 1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 10832–7. Bibcode:1996PNAS...9310832G. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
  9. ^ a b Tanahashi H, Tabira T (Feb 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969. S2CID 54307954.
  10. ^ Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". J. Biol. Chem. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.
  11. ^ a b Trommsdorff M, Borg JP, Margolis B, Herz J (Dec 1998). "Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". J. Biol. Chem. 273 (50): 33556–60. doi:10.1074/jbc.273.50.33556. PMID 9837937.
  12. ^ Borg JP, Ooi J, Levy E, Margolis B (Nov 1996). "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein". Mol. Cell. Biol. 16 (11): 6229–41. doi:10.1128/mcb.16.11.6229. PMC 231626. PMID 8887653.
  13. ^ Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T (Mar 1997). "Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins". J. Biol. Chem. 272 (10): 6399–405. doi:10.1074/jbc.272.10.6399. PMID 9045663.

External links[edit]

Further reading[edit]