APC internal ribosome entry site (IRES)

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APC internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_APC
Rfam RF00462
Other data
RNA type Cis-reg; IRES
Domain(s) Eukaryota
GO 0043022
SO 0000243

The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]


  1. ^ Heppner, Goss K; Trzepacz C; Tuohy TM; Groden J (2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proc Natl Acad Sci USA 99 (12): 8161–8166. doi:10.1073/pnas.112072199. PMC 123038. PMID 12034871. 

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