APOA2

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Apolipoprotein A-II
Protein APOA2 PDB 1l6l.png
Rendering of 1L6L
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APOA2 ; Apo-AII; ApoA-II; apoAII
External IDs OMIM107670 MGI88050 HomoloGene1242 GeneCards: APOA2 Gene
RNA expression pattern
PBB GE APOA2 219466 s at tn.png
PBB GE APOA2 219465 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 336 11807
Ensembl ENSG00000158874 ENSMUSG00000005681
UniProt P02652 P09813
RefSeq (mRNA) NM_001643 NM_013474
RefSeq (protein) NP_001634 NP_038502
Location (UCSC) Chr 1:
161.19 – 161.19 Mb
Chr 1:
171.23 – 171.23 Mb
PubMed search [1] [2]
ApoA-II
PDB 1l6l EBI.jpg
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol ApoA-II
Pfam PF04711
InterPro IPR006801
SCOP 1l6k
SUPERFAMILY 1l6k

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[1]

Function[edit]

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[2]

Interactions[edit]

APOA2 has been shown to interact with PLTP.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ Tsao YK, Wei CF, Robberson DL, Gotto AM Jr, Chan L (Jan 1986). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". J Biol Chem 260 (28): 15222–31. PMID 2415515. 
  2. ^ "Entrez Gene: APOA2 apolipoprotein A-II". 
  3. ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (January 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. PMID 9469594. 

Further reading[edit]