APOA4

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Apolipoprotein A-IV
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APOA4 ; MGC142154; MGC142156
External IDs OMIM107690 MGI88051 HomoloGene47927 GeneCards: APOA4 Gene
RNA expression pattern
PBB GE APOA4 206894 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 337 11808
Ensembl ENSG00000110244 ENSMUSG00000032080
UniProt P06727 P06728
RefSeq (mRNA) NM_000482 NM_007468
RefSeq (protein) NP_000473 NP_031494
Location (UCSC) Chr 11:
116.69 – 116.69 Mb
Chr 9:
46.24 – 46.24 Mb
PubMed search [1] [2]

Apolipoprotein A-IV (also known as apoA-IV, apoAIV, or apoA4) is plasma protein that is the product of the human gene APOA4.[1][2]

Gene[edit]

APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polymorphisms occur in exon 3. The best validated and studied non-synonymous SNPs are a glutaminehistidine substitution at codon 360 and a threonineserine substitution at codon 347; a sequence polymorphism has also been identified in the 3'UTR of the third exon.[3] Intra-species comparative gene sequence analysis suggests that the APOA4 gene arose from APOA1 by gene duplication approximately 270 MYA.[4]

Function[edit]

The primary translation product of the APOA4 gene is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-residue mature O-linked glycoprotein. In most mammals, including humans, apo A-IV synthesis is confined to the intestine; however in mice and rats hepatic synthesis also occurs. Apo A-IV is secreted into circulation on the surface of newly synthesized chylomicron particles. Intestinal fat absorption dramatically increases the synthesis and secretion of apo A-IV. Although its primary function in human lipid metabolism has not been established, apo A-IV has been found to:

Human apo A-IV deficiency has not been reported.

Interactions[edit]

APOA4 has been shown to interact with GPLD1.[5]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE (November 1986). "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)". Proceedings of the National Academy of Sciences of the United States of America 83 (22): 8457–61. doi:10.1073/pnas.83.22.8457. PMC 386949. PMID 3095836. 
  2. ^ Elshourbagy NA, Walker DW, Paik YK, Boguski MS, Freeman M, Gordon JI, Taylor JM (June 1987). "Structure and expression of the human apolipoprotein A-IV gene". J. Biol. Chem. 262 (17): 7973–81. PMID 3036793. 
  3. ^ a b "Entrez Gene: APOA4 apolipoprotein A-IV". 
  4. ^ Luo CC, Li WH, Moore MN, Chan L (February 1986). "Structure and evolution of the apolipoprotein multigene family". J.Mol Biol. 187 (3): 325–340. doi:10.1016/0022-2836(86)90436-5. PMID 3084795. 
  5. ^ Deeg, M A; Bierman E L; Cheung M C (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". J. Lipid Res. (United States) 42 (3): 442–51. ISSN 0022-2275. PMID 11254757. 

Further reading[edit]

External links[edit]