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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Symbols APOBEC3B ; A3B; APOBEC1L; ARCD3; ARP4; DJ742C19.2; PHRBNL; bK150C2.2
External IDs OMIM607110 HomoloGene105420 GeneCards: APOBEC3B Gene
RNA expression pattern
PBB GE APOBEC3B 206632 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9582 80287
Ensembl ENSG00000179750 ENSMUSG00000009585
UniProt Q9UH17 Q3U5C5
RefSeq (mRNA) NM_001270411 NM_001160415
RefSeq (protein) NP_001257340 NP_001153887
Location (UCSC) Chr 22:
39.38 – 39.39 Mb
Chr 15:
79.89 – 79.92 Mb
PubMed search [1] [2]

Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.[1][2][3]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.[3]


  1. ^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358. 
  2. ^ Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE (Sep 1999). "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1". J Invest Dermatol 113 (2): 162–9. doi:10.1046/j.1523-1747.1999.00682.x. PMID 10469298. 
  3. ^ a b "Entrez Gene: APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B". 

Further reading[edit]