APOBEC3F

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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APOBEC3F ; A3F; ARP8; BK150C2.4.MRNA; KA6
External IDs OMIM608993 MGI1933111 HomoloGene105867 ChEMBL: 1741217 GeneCards: APOBEC3F Gene
EC number 3.5.4.-
Orthologs
Species Human Mouse
Entrez 200316 80287
Ensembl ENSG00000128394 ENSMUSG00000009585
UniProt Q8IUX4 Q99J72
RefSeq (mRNA) NM_001006666 NM_030255
RefSeq (protein) NP_001006667 NP_084531
Location (UCSC) Chr 22:
39.44 – 39.45 Mb
Chr 15:
79.72 – 79.74 Mb
PubMed search [1] [2]

DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.[1][2][3]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References[edit]

  1. ^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358. 
  2. ^ Holmes RK, Koning FA, Bishop KN, Malim MH (Jan 2007). "APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G". J Biol Chem 282 (4): 2587–95. doi:10.1074/jbc.M607298200. PMID 17121840. 
  3. ^ a b "Entrez Gene: APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F". 

Further reading[edit]