APOBEC3H

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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Identifiers
Symbols APOBEC3H ; A3H; ARP10
External IDs OMIM610976 HomoloGene52306 GeneCards: APOBEC3H Gene
EC number 3.5.4.-
Orthologs
Species Human Mouse
Entrez 164668 n/a
Ensembl ENSG00000100298 n/a
UniProt Q6NTF7 n/a
RefSeq (mRNA) NM_001166002 n/a
RefSeq (protein) NP_001159474 n/a
Location (UCSC) Chr 22:
39.49 – 39.5 Mb
n/a
PubMed search [1] n/a

DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a protein that in humans is encoded by the APOBEC3H gene.[1]

Function[edit]

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistance to human immunodeficiency virus type 1 infection in certain populations.

References[edit]

Further reading[edit]