DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a protein that in humans is encoded by the APOBEC3Hgene.
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistance to human immunodeficiency virus type 1 infection in certain populations.
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Vartanian JP, Guétard D, Henry M, Wain-Hobson S (2008). "Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions". Science320 (5873): 230–3. doi:10.1126/science.1153201. PMID18403710.