APOBEC4

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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
Identifiers
Symbols APOBEC4 ; C1orf169
External IDs OMIM609908 MGI1918531 HomoloGene52415 GeneCards: APOBEC4 Gene
EC number 3.5.4.-
Orthologs
Species Human Mouse
Entrez 403314 71281
Ensembl ENSG00000173627 ENSMUSG00000055547
UniProt Q8WW27 Q497M3
RefSeq (mRNA) NM_203454 NM_001081197
RefSeq (protein) NP_982279 NP_001074666
Location (UCSC) Chr 1:
183.62 – 183.62 Mb
Chr 1:
152.75 – 152.76 Mb
PubMed search [1] [2]

C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene.[1][2]

Function[edit]

This gene encodes a member of the AID / APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.[2]

References[edit]

  1. ^ Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV (September 2005). "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis". Cell Cycle 4 (9): 1281–5. doi:10.4161/cc.4.9.1994. PMID 16082223. 
  2. ^ a b "Entrez Gene: apolipoprotein B mRNA editing enzyme". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.