APPBP1

NEDD8 activating enzyme E1 subunit 1
	; PDB rendering based on 1r4m.
Available structures
PDB	1R4M, 1R4N, 1TT5, 1YOV, 2NVU, 3DBH, 3DBL, 3DBR, 3GZN
Identifiers
Symbols	NAE1; A-116A10.1; APPBP1; ula-1
External IDs	OMIM: 603385 MGI: 2384561 HomoloGene: 68370 GeneCards: NAE1 Gene
Gene Ontology
Molecular function	• catalytic activity; • protein binding; • NEDD8 activating enzyme activity; • protein heterodimerization activity;
Cellular component	• insoluble fraction; • cytoplasm; • plasma membrane;
Biological process	• DNA replication; • induction of apoptosis; • cell cycle; • signal transduction; • mitotic cell cycle DNA replication checkpoint; • regulation of apoptosis; • protein neddylation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.^[1]^[2]^[3]

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.^[3]

[edit] Interactions

APPBP1 has been shown to interact with UBE1C,^[4] TRIP12^[5] and Amyloid precursor protein.^[1]

[edit] References

^ ^a ^b Chow N, Korenberg JR, Chen XN, Neve RL (Jun 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". J Biol Chem 271 (19): 11339–46. doi:10.1074/jbc.271.19.11339. PMID 8626687.
^ Bohnsack RN, Haas AL (Jul 2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer". J Biol Chem 278 (29): 26823–30. doi:10.1074/jbc.M303177200. PMID 12740388.
^ ^a ^b "Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8883.
^ Chen, Y; McPhie D L, Hirschberg J, Neve R L (Mar. 2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. (UNITED STATES) 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740.
^ Park, Yoon; Yoon Sungjoo Kim, Yoon Jong-Bok (Sep. 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. (United States) 374 (2): 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

[edit] Further reading

Gong L, Yeh ET (1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway". J. Biol. Chem. 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. PMID 10207026.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Hori T, Osaka F, Chiba T, et al. (2000). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293.
Chen Y, McPhie DL, Hirschberg J, Neve RL (2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons". J. Biol. Chem. 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. PMID 10722740.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Walden H, Podgorski MS, Schulman BA (2003). "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8". Nature 422 (6929): 330–4. doi:10.1038/nature01456. PMID 12646924.
Chen Y, Liu W, Naumovski L, Neve RL (2003). "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis". J. Neurochem. 85 (3): 801–9. doi:10.1046/j.1471-4159.2003.01727.x. PMID 12694406.
Chen Y, Liu W, McPhie DL, et al. (2003). "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain". J. Cell Biol. 163 (1): 27–33. doi:10.1083/jcb.200304003. PMC 2173435. PMID 14557245. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173435.
Walden H, Podgorski MS, Huang DT, et al. (2004). "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1". Mol. Cell 12 (6): 1427–37. doi:10.1016/S1097-2765(03)00452-0. PMID 14690597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Huang DT, Miller DW, Mathew R, et al. (2004). "A unique E1–E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8". Nat. Struct. Mol. Biol. 11 (10): 927–35. doi:10.1038/nsmb826. PMC 2862556. PMID 15361859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2862556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Hiller M, Huse K, Szafranski K, et al. (2007). "Single-Nucleotide Polymorphisms in NAGNAG Acceptors Are Highly Predictive for Variations of Alternative Splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1380236.
Norman JA, Shiekhattar R (2006). "Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications". Biochemistry 45 (9): 3014–9. doi:10.1021/bi052435a. PMID 16503656.
Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.