APPBP2

Amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Identifiers
Symbols	APPBP2; HS.84084; KIAA0228; PAT1
External IDs	OMIM: 605324 MGI: 1914134 HomoloGene: 31378 GeneCards: APPBP2 Gene
Gene Ontology Molecular function • microtubule motor activity • protein binding Cellular component • nucleus • cytoplasm • cytoskeleton • microtubule • microtubule associated complex • membrane • cytoplasmic vesicle membrane Biological process • intracellular protein transport • intracellular transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10513	66884
Ensembl	ENSG00000062725	ENSMUSG00000018481
UniProt	Q92624	n/a
RefSeq (mRNA)	NM_006380	NM_025825.3
RefSeq (protein)	NP_006371	NP_080101.1
Location (UCSC)	Chr 17: 58.52 – 58.6 Mb	Chr 11: 85 – 85.05 Mb
PubMed search	[1]	[2]

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein.

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502. 
• Bärlund M, Monni O, Kononen J, et al. (2000). "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.". Cancer Res. 60 (19): 5340–4. PMID 11034067. 
• Monni O, Barlund M, Mousses S, et al. (2001). "Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5711–6. doi:10.1073/pnas.091582298. PMC 33278. PMID 11331760. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33278. 
• Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14979–84. doi:10.1073/pnas.261463298. PMC 64969. PMID 11742091. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64969. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Benboudjema L, Mulvey M, Gao Y, et al. (2003). "Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.". J. Virol. 77 (17): 9192–203. doi:10.1128/JVI.77.17.9192-9203.2003. PMC 187382. PMID 12915535. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187382. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.