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Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols APPL2 ; DIP13B
External IDs OMIM606231 MGI2384914 HomoloGene10046 GeneCards: APPL2 Gene
RNA expression pattern
PBB GE APPL2 218218 at tn.png
More reference expression data
Species Human Mouse
Entrez 55198 216190
Ensembl ENSG00000136044 ENSMUSG00000020263
UniProt Q8NEU8 Q8K3G9
RefSeq (mRNA) NM_001251904 NM_145220
RefSeq (protein) NP_001238833 NP_660255
Location (UCSC) Chr 12:
105.57 – 105.63 Mb
Chr 10:
83.6 – 83.65 Mb
PubMed search [1] [2]

DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.[1][2][3]

Model organisms[edit]

Model organisms have been used in the study of APPL2 function. A conditional knockout mouse line, called Appl2tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.[6]


  1. ^ Bonaglia MC, Giorda R, Borgatti R, Felisari G, Gagliardi C, Selicorni A, Zuffardi O (Jul 2001). "Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome". Am J Hum Genet 69 (2): 261–8. doi:10.1086/321293. PMC 1235301. PMID 11431708. 
  2. ^ Nechamen CA, Thomas RM, Dias JA (Nov 2006). "APPL1, APPL2, Akt2 and FOXO1a Interact with FSHR in a Potential Signaling Complex". Mol Cell Endocrinol. 260-262: 93–9. doi:10.1016/j.mce.2006.08.014. PMC 1782224. PMID 17030088. 
  3. ^ "Entrez Gene: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2". 
  4. ^ "Salmonella infection data for Appl2". Wellcome Trust Sanger Institute. 
  5. ^ "Citrobacter infection data for Appl2". Wellcome Trust Sanger Institute. 
  6. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  7. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  8. ^ "International Knockout Mouse Consortium". 
  9. ^ "Mouse Genome Informatics". 
  10. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  11. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  12. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  13. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]