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For other meanings, see Araf (disambiguation).
A-Raf proto-oncogene, serine/threonine kinase
Protein ARAF PDB 1wxm.png
PDB rendering based on 1wxm.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARAF ; A-RAF; ARAF1; PKS2; RAFA1
External IDs OMIM311010 MGI88065 HomoloGene1249 ChEMBL: 1169596 GeneCards: ARAF Gene
EC number
RNA expression pattern
PBB GE ARAF 201895 at tn.png
More reference expression data
Species Human Mouse
Entrez 369 11836
Ensembl ENSG00000078061 ENSMUSG00000001127
UniProt P10398 P04627
RefSeq (mRNA) NM_001256196 NM_001159645
RefSeq (protein) NP_001243125 NP_001153117
Location (UCSC) Chr X:
47.42 – 47.43 Mb
Chr X:
20.8 – 20.86 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene.[1] A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.[2]


ARAF has been shown to interact with:


  1. ^ "Entrez Gene: ARAF V-raf murine sarcoma 3611 viral oncogene homolog". 
  2. ^ Mark GE, Seeley TW, Shows TB, Mountz JD (September 1986). "Pks, a raf-related sequence in humans". Proc. Natl. Acad. Sci. U.S.A. 83 (17): 6312–6. doi:10.1073/pnas.83.17.6312. PMC 386493. PMID 3529082. 
  3. ^ a b c d e Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. 
  4. ^ Yin XL, Chen S, Yan J, Hu Y, Gu JX (February 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. PMID 11909642. 
  5. ^ a b c Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. 
  6. ^ Yin XL, Chen S, Gu JX (February 2002). "Identification of TH1 as an interaction partner of A-Raf kinase". Mol. Cell. Biochem. 231 (1–2): 69–74. doi:10.1023/A:1014437024129. PMID 11952167. 

Further reading[edit]