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ADP-ribosylation factor 4
Protein ARF4 PDB 1z6x.png
PDB rendering based on 1z6x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARF4 ; ARF2
External IDs OMIM601177 MGI99433 HomoloGene55593 GeneCards: ARF4 Gene
RNA expression pattern
PBB GE ARF4 201097 s at tn.png
PBB GE ARF4 201096 s at tn.png
More reference expression data
Species Human Mouse
Entrez 378 11843
Ensembl ENSG00000168374 ENSMUSG00000021877
UniProt P18085 P61750
RefSeq (mRNA) NM_001660 NM_007479
RefSeq (protein) NP_001651 NP_031505
Location (UCSC) Chr 3:
57.56 – 57.58 Mb
Chr 14:
26.64 – 26.67 Mb
PubMed search [1] [2]

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.[1][2]


ADP-ribosylation factor 4 (ARF4) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1 and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. The ARF4 is the most divergent member of the human ARFs. Conflicting Map positions at 3p14 or 3p21 have been reported for this gene.[2]


ARF4 has been shown to interact with Epidermal growth factor receptor.[3]


  1. ^ Monaco L, Murtagh JJ, Newman KB, Tsai SC, Moss J, Vaughan M (Apr 1990). "Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2206–10. doi:10.1073/pnas.87.6.2206. PMC 53655. PMID 2107548. 
  2. ^ a b "Entrez Gene: ARF4 ADP-ribosylation factor 4". 
  3. ^ Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD (Jan 2003). "ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation". J. Biol. Chem. 278 (4): 2661–8. doi:10.1074/jbc.M205819200. PMID 12446727. 

Further reading[edit]