ARF5

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ADP-ribosylation factor 5
Protein ARF5 PDB 1z6x.png
PDB rendering based on 1z6x.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol ARF5
External IDs OMIM103188 MGI99434 HomoloGene129625 ChEMBL: 5986 GeneCards: ARF5 Gene
RNA expression pattern
PBB GE ARF5 201526 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 381 11844
Ensembl ENSG00000004059 ENSMUSG00000020440
UniProt P84085 P84084
RefSeq (mRNA) NM_001662 NM_007480
RefSeq (protein) NP_001653 NP_031506
Location (UCSC) Chr 7:
127.23 – 127.23 Mb
Chr 6:
28.42 – 28.43 Mb
PubMed search [1] [2]

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.[1][2]

ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.[2]

Interactions[edit]

ARF5 has been shown to interact with ARFIP2.[3][4]

References[edit]

  1. ^ Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M (March 1991). "Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells". J Biol Chem 266 (5): 2772–7. PMID 1993656. 
  2. ^ a b "Entrez Gene: ARF5 ADP-ribosylation factor 5". 
  3. ^ Kanoh, H; Williger B T; Exton J H (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J. Biol. Chem. (UNITED STATES) 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. ISSN 0021-9258. PMID 9038142. 
  4. ^ Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. (United States) 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. ISSN 0006-291X. PMID 11478794. 

Further reading[edit]