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ADP-ribosylation factor 5
Protein ARF5 PDB 1z6x.png
PDB rendering based on 1z6x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol ARF5
External IDs OMIM103188 MGI99434 HomoloGene129625 ChEMBL: 5986 GeneCards: ARF5 Gene
RNA expression pattern
PBB GE ARF5 201526 at tn.png
More reference expression data
Species Human Mouse
Entrez 381 11844
Ensembl ENSG00000004059 ENSMUSG00000020440
UniProt P84085 P84084
RefSeq (mRNA) NM_001662 NM_007480
RefSeq (protein) NP_001653 NP_031506
Location (UCSC) Chr 7:
127.23 – 127.23 Mb
Chr 6:
28.42 – 28.43 Mb
PubMed search [1] [2]

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.[1][2]

ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.[2]


ARF5 has been shown to interact with ARFIP2.[3][4]


  1. ^ Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M (March 1991). "Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells". J Biol Chem 266 (5): 2772–7. PMID 1993656. 
  2. ^ a b "Entrez Gene: ARF5 ADP-ribosylation factor 5". 
  3. ^ Kanoh, H; Williger B T; Exton J H (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J. Biol. Chem. (UNITED STATES) 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. ISSN 0021-9258. PMID 9038142. 
  4. ^ Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. (United States) 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. ISSN 0006-291X. PMID 11478794. 

Further reading[edit]